Deep Dive · Video Series

The Pulse

Our new video series on deep scientific topics
hosted by NaNotics Chief R&D Officer, Curtis Ruegg, Ph.D.

Episode 1

The role of TNF & sTNF‑Rs in the Cancer Immunity Cycle (CIC)

In this episode, Dr. Ruegg explains how TNF potentiates every step of the CIC – the process by which the immune system fights cancer – and how soluble TNF receptors (sTNF‑Rs) block the CIC at every step. Finally Dr. Ruegg presents experimental data showing that NaNots against sTNF‑Rs restore each step of the CIC in a cancer model.

Episode 2

COMING SOON: NaNots for Treatment of Multiple Sclerosis

In this upcoming episode, Dr. Ruegg explains the roles of soluble TNF, membrane TNF, and the soluble receptors of TNF in the etiology of MS, and how NaNots against 3 of these targets yielded an outcome never before achieved with a drug in the standard mouse model of MS.